Training Fellowship - Australian Based Biomedical Fellowship

Role of plasmodium falciparum protein GEXP07 in Maurer’s Cleft morphology, Knob architecture, and P. Falciparum EMP1 trafficking

E McHugh, OMS Carmo, A Blanch, O Looker, B Liu, S Tiash, D Andrew, S Batinovic, AJY Low, HJ Cho, P McMillan, L Tilley, MWA Dixon

2020-01-01

The malaria parasite Plasmodium falciparum traffics the virulence protein P. falciparum erythrocyte membrane protein 1 (PfEMP1) to..

The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly

O Looker, AJ Blanch, B Liu, J Nunez-Iglesias, PJ McMillan, L Tilley, MWA Dixon

2019-05-01

Plasmodium falciparum mediates adhesion of infected red blood cells (RBCs) to blood vessel walls by assembling a multi-protein com..

Disrupting assembly of the inner membrane complex blocks Plasmodium falciparum sexual stage development

M Parkyn Schneider, B Liu, P Glock, A Suttie, E McHugh, D Andrew, S Batinovic, N Williamson, E Hanssen, P McMillan, M Hliscs, L Tilley, MWA Dixon

2017-10-01

Transmission of malaria parasites relies on the formation of a specialized blood form called the gametocyte. Gametocytes of the hu..

A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability

FL da Silva, MWA Dixon, CM Stack, F Teuscher, E Taran, MK Jones, E Lovas, L Tilley, CL Brown, KR Trenholme, JP Dalton, DL Gardiner, TS Skinner-Adams

2016-10-01

Infection with the apicomplexan parasite Plasmodium falciparum is a major cause of morbidity and mortality worldwide. One of the s..

Reversible host cell remodeling underpins deformability changes in malaria parasite sexual blood stages

M Dearnley, T Chu, Y Zhang, O Looker, C Huang, N Klonis, J Yeoman, S Kenny, M Arora, JM Osborne, R Chandramohanadas, S Zhang, MWA Dixon, L Tilley

2016-04-26

The sexual blood stage of the human malaria parasite Plasmodium falciparum undergoes remarkable biophysical changes as it prepares..

Organization and function of an actin cytoskeleton in Plasmodium falciparum gametocytes

M Hliscs, C Millet, MW Dixon, I Siden-Kiamos, P Mcmillan, L Tilley

2015-02-01

In preparation for transmission to its mosquito vector, Plasmodium falciparum, the most virulent of the human malaria parasites, a..

Red blood cells polarize green laser light revealing hemoglobin's enhanced non-fundamental Raman modes

KM Marzec, D Perez-Guaita, M De Veij, D McNaughton, M Baranska, MWA Dixon, L Tilley, BR Wood

2014-10-20

In general, the first overtone modes produce weak bands that appear at approximately twice the wavenumber value of the fundamental..

Diagnosing malaria infected cells at the single cell level using focal plane array Fourier transform infrared imaging spectroscopy

BR Wood, KR Bambery, MWA Dixon, L Tilley, MJ Nasse, E Mattson, CJ Hirschmugl

2014-08-26

New methods are needed to rapidly identify malaria parasites in blood smears. The coupling of a Focal Plane Array (FPA) infrared m..

Detection and quantification of early-stage malaria parasites in laboratory infected erythrocytes by attenuated total reflectance infrared spectroscopy and multivariate analysis

A Khoshmanesh, MWA Dixon, S Kenny, L Tilley, D McNaughton, BR Wood

2014-05-06

New diagnostic modalities for malaria must have high sensitivity and be affordable to the developing world. We report on a method ..

A female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite

PN Tran, SHJ Brown, TW Mitchell, K Matuschewski, PJ McMillan, K Kirk, MWA Dixon, AG Maier

2014-01-01

ATP-binding cassette (ABC) transporters serve a variety of physiological functions as well as play key roles in drug resistance. T..

The Plasmodium translocon of exported proteins (PTEX) component thioredoxin-2 is important for maintaining normal blood-stage growth

K Matthews, M Kalanon, SA Chisholm, A Sturm, CD Goodman, MWA Dixon, PR Sanders, T Nebl, F Fraser, S Haase, GI Mcfadden, PR Gilson, BS Crabb, TF De Koning-Ward

2013-09-01

Summary: Plasmodium parasites remodel their vertebrate host cells by translocating hundreds of proteins across an encasing membran..

Spatial and temporal mapping of the PfEMP1 export pathway in Plasmodium falciparum

PJ Mcmillan, C Millet, S Batinovic, M Maiorca, E Hanssen, S Kenny, RA Muhle, M Melcher, DA Fidock, JD Smith, MWA Dixon, L Tilley

2013-08-01

The human malaria parasite, Plasmodium falciparum, modifies the red blood cells (RBCs) that it infects by exporting proteins to th..

Mitochondrial metabolism of sexual and asexual blood stages of the malaria parasite Plasmodium falciparum

JI MacRae, MWA Dixon, MK Dearnley, HH Chua, JM Chambers, S Kenny, I Bottova, L Tilley, MJ McConville

2013-06-13

Background: The carbon metabolism of the blood stages of Plasmodium falciparum, comprising rapidly dividing asexual stages and non..

Temporal evaluation of commitment to sexual development in Plasmodium falciparum

CL Peatey, MW Dixon, DL Gardiner, KR Trenholme

2013-05-01

Background: The production of gametocytes is essential for transmission of malaria parasites from the mammalian host to the mosqui..